Κάντε click στον τίτλο για να δείτε τα highlights από τα παιχνίδια στον επίσημο ιστότοπο της UEFA.
Matchday 1 : 20 September 2012
| Young Boys |  | 3-5 |  | Liverpool |
| Referee: Michael Koukoulakis (GRE) – Stadium: Stade de Suisse, Berne (SUI) | ||||
| Udinese |  | 1-1 |  | Anzhi |
| Referee: Hüseyin Göçek (TUR) – Stadium: Stadio Friuli, Udine (ITA) | ||||
| H. Tel-Aviv |  | 0-3 |  | Atlético |
| Referee: Pol van Boekel (NED) – Stadium: Itztadion Bloomfield, Tel Aviv (ISR) | ||||
| Plzeň |  | 3-1 |  | Académica |
| Referee: Hannes Kaasik (EST) – Stadium: Stadion města Plzně, Plzen (CZE) | ||||
| AEL |  | 0-0 |  | Mönchengladbach |
| Referee: Duarte Gomes (POR) – Stadium: GSP Stadium, Nicosia (CYP) | ||||
| Fenerbahçe |  | 2-2 |  | Marseille |
| Referee: Ivan Bebek (CRO) – Stadium: Şükrü Saracoğlu, Istanbul (TUR) | ||||
| Marítimo |  | 0-0 |  | Newcastle |
| Referee: Robert Schörgenhofer (AUT) – Stadium: Dos Barreiros, Funchal (POR) | ||||
| Bordeaux |  | 4-0 |  | Club Brugge |
| Referee: Vladislav Bezborodov (RUS) – Stadium: Stade Chaban-Delmas, Bordeaux (FRA) | ||||
| Stuttgart |  | 2-2 |  | Steaua |
| Referee: Serge Gumienny (BEL) – Stadium: VfB Arena, Stuttgart (GER) | ||||
| København |  | 2-1 |  | Molde |
| Referee: Antti Munukka (FIN) – Stadium: Parken, Copenhagen (DEN) | ||||
| Dnipro |  | 2-0 |  | PSV |
| Referee: Miroslav Zelinka (CZE) – Stadium: Dnipro Arena, Dnipropetrovsk (UKR) | ||||
| Napoli |  | 4-0 |  | AIK |
| Referee: Clément Turpin (FRA) – Stadium: Stadio San Paolo, Naples (ITA) | ||||
| Genk |  | 3-0 |  | Videoton |
| Referee: Laurent Duhamel (FRA) – Stadium: KRC Genk Arena, Genk (BEL) | ||||
| Sporting |  | 0-0 |  | Basel |
| Referee: Alon Yefet (ISR) – Stadium: José Alvalade, Lisbon (POR) | ||||
| Internazionale |  | 2-2 |  | Rubin |
| Referee: Deniz Aytekin (GER) – Stadium: Stadio Giuseppe Meazza, Milan (ITA) | ||||
| Partizan |  | 0-0 |  | Neftçi |
| Referee: Libor Kovařik (CZE) – Stadium: FK Partizan, Belgrade (SRB) | ||||
| Lyon |  | 2-1 |  | Sparta Praha |
| Referee: Serhiy Boiko (UKR) – Stadium: Stade de Gerland, Lyon (FRA) | ||||
| Athletic |  | 1-1 |  | H. Kiryat Shmona |
| Referee: Simon Lee Evans (WAL) – Stadium: Estadio de San Mamés, Bilbao (ESP) | ||||
| Maribor |  | 3-0 |  | Panathinaikos |
| Referee: Alan Kelly (IRL) – Stadium: Stadion Ljudski vrt, Maribor (SVN) | ||||
| Tottenham |  | 0-0 |  | Lazio |
| Referee: Ovidiu Alin Hategan (ROU) – Stadium: White Hart Lane, London (ENG) | ||||
| Rapid Wien |  | 1-2 |  | Rosenborg |
| Referee: Stanislav Todorov (BUL) – Stadium: Ernst-Happel-Stadion, Vienna (AUT) | ||||
| Leverkusen |  | 0-0 |  | Metalist |
| Referee: Martin Hansson (SWE) – Stadium: BayArena, Leverkusen (GER) | ||||
| Levante |  | 1-0 |  | Helsingborg |
| Referee: Aleksei Kulbakov (BLR) – Stadium: Estadi Ciutat de València, Valencia (ESP) | ||||
| Twente |  | 2-2 |  | Hannover |
